Ph.D. Student, Biological Sciences
Vanderbilt University, Nashville, TN
Beginning graduate study following completion of my B.S. at the University of Tennessee, Knoxville.
Graham Cole Goforth
1Ph.D. in Biological Sciences, Vanderbilt University · 2B.S. Honors Biochemistry & Cellular/Molecular Biology, University of Tennessee
I study how the components of a lipid nanoparticle determine what it can actually deliver. My undergraduate thesis substituted DOPE for conventional helper lipids and asked what that trade buys you — testing whether a cone-shaped, fusogenic phospholipid improves endosomal escape enough to justify the stability you give up relative to cylindrical DSPC.
That question sits at the intersection of formulation chemistry and cell biology, which is where I want to keep working. Alongside the bench, teaching has become a second thread: I've assisted two laboratory courses at UT, and I care about the part of science that only counts once someone else can follow it.
Vanderbilt University, Nashville, TN
Beginning graduate study following completion of my B.S. at the University of Tennessee, Knoxville.
Undergraduate honors thesis · Vascular Research Laboratory, UT Graduate School of Medicine · PI: Dr. Deidra Mountain
Formulated LNPs across a range of DOPE concentrations, then measured encapsulation efficiency, size and polydispersity by DLS, in vitro cytotoxicity, and fluorescent uptake in human aortic smooth muscle cells. Read the thesis →
Molecular oncology literature analysis · Mentor: Dr. Jacob Sanders
Systematic review of preclinical evidence for wogonoside, a flavonoid from Scutellaria baicalensis, tracing its suppression of tumor angiogenesis and metastatic signaling through Hedgehog and Wnt/β-catenin pathways.
Best Organic Synthesis Lab, Department of Chemistry, UT Knoxville · PI: Dr. Jinchao Lou
Multi-step organic synthesis under inert atmosphere, with structural validation by 1H-NMR, FT-IR, UV-Vis, and GC-MS.