Graham Cole Goforth

A lipid’s shape decides whether the cargo ever gets out of the endosome.

1Ph.D. in Biological Sciences, Vanderbilt University  ·  2B.S. Honors Biochemistry & Cellular/Molecular Biology, University of Tennessee

Focus  Lipid nanoparticles for RNA delivery Advisor, thesis  Dr. Deidra Mountain Based in  Nashville, TN

I study how the components of a lipid nanoparticle determine what it can actually deliver. My undergraduate thesis substituted DOPE for conventional helper lipids and asked what that trade buys you — testing whether a cone-shaped, fusogenic phospholipid improves endosomal escape enough to justify the stability you give up relative to cylindrical DSPC.

That question sits at the intersection of formulation chemistry and cell biology, which is where I want to keep working. Alongside the bench, teaching has become a second thread: I've assisted two laboratory courses at UT, and I care about the part of science that only counts once someone else can follow it.

Current position

Aug 2026 –

Ph.D. Student, Biological Sciences

Vanderbilt University, Nashville, TN

Beginning graduate study following completion of my B.S. at the University of Tennessee, Knoxville.

Selected work

2025–2026

DOPC/DOPE-dependent Effects on Lipid Nanoparticle Stability, Encapsulation, Cytotoxicity, and Cellular Uptake

Undergraduate honors thesis · Vascular Research Laboratory, UT Graduate School of Medicine · PI: Dr. Deidra Mountain

Formulated LNPs across a range of DOPE concentrations, then measured encapsulation efficiency, size and polydispersity by DLS, in vitro cytotoxicity, and fluorescent uptake in human aortic smooth muscle cells. Read the thesis →

2025

Natural product–derived cancer therapeutics: wogonoside and its derivatives

Molecular oncology literature analysis · Mentor: Dr. Jacob Sanders

Systematic review of preclinical evidence for wogonoside, a flavonoid from Scutellaria baicalensis, tracing its suppression of tumor angiogenesis and metastatic signaling through Hedgehog and Wnt/β-catenin pathways.

2024

Synthesis of lipid-based biomolecules for drug delivery and lipid-probe development

Best Organic Synthesis Lab, Department of Chemistry, UT Knoxville · PI: Dr. Jinchao Lou

Multi-step organic synthesis under inert atmosphere, with structural validation by 1H-NMR, FT-IR, UV-Vis, and GC-MS.

Areas

Lipid nanoparticles RNA delivery Helper phospholipid geometry Endosomal escape Encapsulation efficiency Vascular smooth muscle Organic synthesis Laboratory teaching